![]() Suspected risk factors include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock.ĪPC mutations are also associated with second hits in key oncogenic pathways, including Kras, Braf, p53, and Smad4, and these mutations drive progression to adenocarcinoma, collectively contributing to disease progression. Today, nearly 10 percent of CRC cases are now diagnosed in people younger than 50 years, and this trend is on a steady rise. However, based on our findings, we now believe that disruption of the circadian clock plays an important role."Īccording to the National Institutes of Health, there has been an alarming rise in early-onset colorectal cancer among young individuals. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. "Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. ![]() "As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior," said Selma Masri, PhD, assistant professor of biological chemistry at UCI School of Medicine. APC point mutations, deletions, and loss of heterozygosity (LOH) events have been reported in ~80 percent of human CRC cases, and it is these mutations that drive the initiation of intestinal adenoma development. In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC). The study, titled, "Disruption of the Circadian Clock drives Apc Loss of Heterozygosity to Accelerate Colorectal Cancer,"was published today in Science Advances.
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